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meca32  (Danaher Inc)


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    Structured Review

    Danaher Inc meca32
    Meca32, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/meca32/pm39001820-161-25-31
    Average 86 stars, based on 1 article reviews
    meca32 - by Bioz Stars, 2026-09
    86/100 stars

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    Related Articles

    Staining:

    Article Title: Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms.
    Article Snippet: .. The samples were double stained with CD68 (ab53444, rat antimouse recombinant antibody, Abcam, 1:100) and FSP-1 (ab197896, rabbit antimouse recombinant antibody, Abcam, 1:125) and also MECA32 (ab27853, rat antimouse recombinant antibody, Abcam, 1:500) and αSMC (ab5694, rabbit antimouse recombinant antibody, Abcam, 1:100). .. Also, samples were single stained with CD80 (ab254579, rabbit antimouse recombinant antibody, Abcam, 1:50) and CD206 (ab300621, rabbit antimouse antibody, Abcam, 1:50).

    Article Title: Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms
    Article Snippet: .. The samples were double stained with CD68 (ab53444, rat antimouse recombinant antibody, Abcam, 1:100) and FSP-1 (ab197896, rabbit antimouse recombinant antibody, Abcam, 1:125) and also MECA32 (ab27853, rat antimouse recombinant antibody, Abcam, 1:500) and αSMC (ab5694, rabbit antimouse recombinant antibody, Abcam, 1:100). .. Also, samples were single stained with CD80 (ab254579, rabbit antimouse recombinant antibody, Abcam, 1:50) and CD206 (ab300621, rabbit antimouse antibody, Abcam, 1:50).

    Recombinant:

    Article Title: Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms.
    Article Snippet: .. The samples were double stained with CD68 (ab53444, rat antimouse recombinant antibody, Abcam, 1:100) and FSP-1 (ab197896, rabbit antimouse recombinant antibody, Abcam, 1:125) and also MECA32 (ab27853, rat antimouse recombinant antibody, Abcam, 1:500) and αSMC (ab5694, rabbit antimouse recombinant antibody, Abcam, 1:100). .. Also, samples were single stained with CD80 (ab254579, rabbit antimouse recombinant antibody, Abcam, 1:50) and CD206 (ab300621, rabbit antimouse antibody, Abcam, 1:50).

    Article Title: Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms
    Article Snippet: .. The samples were double stained with CD68 (ab53444, rat antimouse recombinant antibody, Abcam, 1:100) and FSP-1 (ab197896, rabbit antimouse recombinant antibody, Abcam, 1:125) and also MECA32 (ab27853, rat antimouse recombinant antibody, Abcam, 1:500) and αSMC (ab5694, rabbit antimouse recombinant antibody, Abcam, 1:100). .. Also, samples were single stained with CD80 (ab254579, rabbit antimouse recombinant antibody, Abcam, 1:50) and CD206 (ab300621, rabbit antimouse antibody, Abcam, 1:50).



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    HC-5404 sensitizes 786-O xenografts to the antiangiogenic effects of axitinib. A, IHC images of 786-O xenograft sections stained with antibodies specific to <t>Meca32,</t> CD31, and SMA. Scale bar = 150 μm. HC-5404 and axitinib administered at 30 mg/kg, twice-a-day for 7 days. B–D, Quantification of IHC staining of xenograft sections. Graphs indicate proportion of cells stained positive for Meca32, positive for CD31 in absence of SMA (%CD31 + SMA − ), or cells that stain positive for both CD31 and SMA (%CD31 + SMA + ). One-way ANOVA statistical analysis evaluated differences between treatment groups; asterisks indicate significant differences (*, P < 0.05; **, P < 0.01; ****, P < 0.001).
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    Image Search Results


    HC-5404 sensitizes 786-O xenografts to the antiangiogenic effects of axitinib. A, IHC images of 786-O xenograft sections stained with antibodies specific to Meca32, CD31, and SMA. Scale bar = 150 μm. HC-5404 and axitinib administered at 30 mg/kg, twice-a-day for 7 days. B–D, Quantification of IHC staining of xenograft sections. Graphs indicate proportion of cells stained positive for Meca32, positive for CD31 in absence of SMA (%CD31 + SMA − ), or cells that stain positive for both CD31 and SMA (%CD31 + SMA + ). One-way ANOVA statistical analysis evaluated differences between treatment groups; asterisks indicate significant differences (*, P < 0.05; **, P < 0.01; ****, P < 0.001).

    Journal: Clinical Cancer Research

    Article Title: PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors

    doi: 10.1158/1078-0432.CCR-23-1182

    Figure Lengend Snippet: HC-5404 sensitizes 786-O xenografts to the antiangiogenic effects of axitinib. A, IHC images of 786-O xenograft sections stained with antibodies specific to Meca32, CD31, and SMA. Scale bar = 150 μm. HC-5404 and axitinib administered at 30 mg/kg, twice-a-day for 7 days. B–D, Quantification of IHC staining of xenograft sections. Graphs indicate proportion of cells stained positive for Meca32, positive for CD31 in absence of SMA (%CD31 + SMA − ), or cells that stain positive for both CD31 and SMA (%CD31 + SMA + ). One-way ANOVA statistical analysis evaluated differences between treatment groups; asterisks indicate significant differences (*, P < 0.05; **, P < 0.01; ****, P < 0.001).

    Article Snippet: Primary antibodies used were as follows: α-CD31 (Abcam, catalog No. ab182981, RRID:AB_2920881), α-smooth muscle actin (SMA; Abcam, catalog No. ab124964, RRID:AB_11129103), and α-Meca32 (Novus Biologicals, catalog No. NB100–77668, RRID:AB_2276108).

    Techniques: Staining, Immunohistochemistry

    Addition of HC-5404 to axitinib regimen induces tumor regression. A, 786-O tumor growth across the study period. Xenografts that progressed in presence of axitinib for 14 days were rerandomized and transferred to indicated treatment groups for an additional 28 days. Data represent mean ± S.E.M. Final tumor volume analyzed by Welch ANOVA. Data represent mean ± S.E.M., n = 8 mice per group (**, P < 0.01; ***, P < 0.005; ****, P < 0.001). B, IHC images of xenograft sections stained with antibodies specific for CD31 and SMA. C, Quantification of proportion of cells that stained positive for Meca32, CD31+SMA- (immature blood vessels), or CD31 + SMA + (mature blood vessels) in B . One-way ANOVA was used to evaluate the statistical significance between groups. Asterisks indicate statistical significance (*, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.001). D, Quantification of IHC staining of tumor sections using antibodies specific for the pericyte markers NG2 and MCAM. One-way ANOVA statistical analysis evaluated differences between treatment groups; asterisks indicate significant differences (**, P < 0.01; ***, P < 0.005; ****, P < 0.001).

    Journal: Clinical Cancer Research

    Article Title: PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors

    doi: 10.1158/1078-0432.CCR-23-1182

    Figure Lengend Snippet: Addition of HC-5404 to axitinib regimen induces tumor regression. A, 786-O tumor growth across the study period. Xenografts that progressed in presence of axitinib for 14 days were rerandomized and transferred to indicated treatment groups for an additional 28 days. Data represent mean ± S.E.M. Final tumor volume analyzed by Welch ANOVA. Data represent mean ± S.E.M., n = 8 mice per group (**, P < 0.01; ***, P < 0.005; ****, P < 0.001). B, IHC images of xenograft sections stained with antibodies specific for CD31 and SMA. C, Quantification of proportion of cells that stained positive for Meca32, CD31+SMA- (immature blood vessels), or CD31 + SMA + (mature blood vessels) in B . One-way ANOVA was used to evaluate the statistical significance between groups. Asterisks indicate statistical significance (*, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.001). D, Quantification of IHC staining of tumor sections using antibodies specific for the pericyte markers NG2 and MCAM. One-way ANOVA statistical analysis evaluated differences between treatment groups; asterisks indicate significant differences (**, P < 0.01; ***, P < 0.005; ****, P < 0.001).

    Article Snippet: Primary antibodies used were as follows: α-CD31 (Abcam, catalog No. ab182981, RRID:AB_2920881), α-smooth muscle actin (SMA; Abcam, catalog No. ab124964, RRID:AB_11129103), and α-Meca32 (Novus Biologicals, catalog No. NB100–77668, RRID:AB_2276108).

    Techniques: Staining, Immunohistochemistry